期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 30, 期 6, 页码 357-368出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2019.03.003
关键词
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资金
- National Institutes of Health (NIH) [R01-CA046677, R01-CA179542]
- Research Centers in Minority Institutions [RP-03037]
- National Center for Research Resources of the NIH
Cancer cells consume glutamine, a nonessential amino acid (NEAA), at exceedingly high rates to fulfill their energetic and biosynthetic requirements for proliferation. Glutamine plays distinct roles from essential amino acids in cell cycle progression and in the activation of mammalian target of rapamycin (mTOR). Furthermore, the need of cancer cells for glutamine can be exploited therapeutically - especially those driven by KRas. In this review we explore several distinct cellular roles for glutamine that contribute to glutamine addiction in KRas-driven cancer cells and discuss opportunities for therapeutic intervention created by glutamine addiction.
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