期刊
TRENDS IN CELL BIOLOGY
卷 29, 期 9, 页码 695-703出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2019.05.005
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资金
- NCI NIH HHS [P30 CA014236, R00 CA168997, R01 CA193256] Funding Source: Medline
- NIGMS NIH HHS [T32 GM145449, T32 GM007171] Funding Source: Medline
Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support the existence of a de novo pathway for acetate production derived from pyruvate, the end product of glycolysis. This mechanism of pyruvate-derived acetate generation could have far-reaching implications for the regulation of central carbon metabolism. In this Opinion, we discuss our current understanding of acetate metabolism in the context of cell-autonomous metabolic regulation, cell-cell interactions, and systemic physiology. Applications relevant to health and disease, particularly cancer, are emphasized.
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