期刊
TRENDS IN BIOTECHNOLOGY
卷 37, 期 12, 页码 1327-1343出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2019.04.009
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资金
- NHLBI NIH HHS [R01 HL076485] Funding Source: Medline
Microphysiological systems (MPSs) have been proposed as an improved tool to recreate the complex biological features of the native nichewith the goal of improving in vitro-in vivo extrapolation. In just over a decade, MPS technologies have progressed fromsingle-tissue chips tomultitissue plates with integrated pumps for perfusion. Concurrently, techniques for biofabrication of complex 3D constructs for regenerative medicine and 3D in vitro models have evolved into a diverse toolbox for micrometer-scale deposition of cells and cell-laden bioinks. However, as the complexity of biological models increases, experimental throughput is often compromised. This review discusses the existing disparity betweenMPS complexity and throughput, then examines an MPS-terminated biofabrication line to identify the hurdles and potential approaches to over-coming this disparity.
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