期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 44, 期 11, 页码 973-988出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2019.06.002
关键词
-
资金
- National Natural Science Foundation of China [31830001, 31570027, 81772142]
- National Key R&D Program of China [2017YFD0500202]
- national 'Young 1000 Talents' award of China
Polymyxins are a group of detergent-like antimicrobial peptides that are the ultimate line of defense against carbapenem-resistant pathogens in clinical settings. Polymyxin resistance primarily originates from structural remodeling of lipid A anchored on bacterial surfaces. We integrate genetic, structural, and biochemical aspects of three major types of lipid A modifiers that have been shown to confer intrinsic colistin resistance. Namely, we highlight ArnT, a glycosyltransferase, EptA, a phosphoethanolamine transferase, and the AlmEFG tripartite system, which is restricted to EI Tor biotype of Vibrio cholerae O1. We also discuss the growing family of mobile colistin resistance (MCR) enzymes, each of which is analogous to EptA, and which pose great challenges to global public health.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据