期刊
TRANSLATIONAL ONCOLOGY
卷 12, 期 7, 页码 981-986出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.tranon.2019.04.022
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资金
- Fellowship FIRC-AIRC one-year fellowship Laura Bassi [20,879]
Clinical trials using anti-vascular endothelial growth factor /(VEGF) molecules induce a modest improvement in overall survival, measurable in weeks to just a few months, and tumors respond differently to these agents. In this review article, we have exposed some tumor characteristics and processes that may impair the effectiveness of anti-angiogenic approaches, including genotypic changes on endothelial cells, the vascular normalization phenomenon, and the vasculogenic mimicry. The usage of anti-angiogenic molecules leads to hypoxic tumor microenvironment which enhances tumor invasiveness. The role of tumor-infiltrating cells, including tumor associated macrophages and fibroblasts (TAMS and TAFs) in the therapeutic response to anti-angiogenic settings was also highlighted. Finally, among the new therapeutic approaches to target tumor vasculature, anti-PD-1 or antiPD-L1 therapy sensitizing and prolonging the efficacy of anti-angiogenic therapy, have been discussed.
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