Metal-free I2O5-mediated oxidative synthesis of sulfonylated benzofurans through cyclization reaction of 1,6-enynes and arylsulfonylhydrazides

A simple I2O5-mediated method for the construction of sulfonylated benzofurans has been developed under metal-free conditions. The present reaction can be efficiently achieved through the oxidative cyclization of 1,6-enynes and arylsulfonylhydrazides, which provides an attractive approach to a series of sulfonylated benzofurans in moderate to good yields. (C) 2019 Elsevier Ltd. All rights reserved.