期刊
TETRAHEDRON
卷 75, 期 27, 页码 3767-3771出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2019.05.058
关键词
Indolizine; One-pot; Iodine; 1,3-Dipolar cycloaddition
资金
- Chinese Guizhou Provincial Engineering Research Center for Natural Drugs
- West Light Foundation of The Chinese Academy of Sciences
- Natural Science Foundation of Guizhou Province of China [QKHJC[2017]1117, QKHJC[2018]1109, QKHPTRC[2017]5718]
An I-2/CuI-promoted multi-component reaction from pyridines, aryl methyl ketones and electron deficient acrylates has been accomplished in a one-pot manner, which provides a straightforward and efficient access to C-3 acylated indolizines. The key intermediate of N-ylides is hypothesized to be generated in situ from pyridines and (hetero)aryl methyl ketones in the presence of iodine. This method has been applied in the synthesis of two molecules with anticonvulsant and anti-inflammatory activities. (C) 2019 Elsevier Ltd. All rights reserved.
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