期刊
SYNTHESIS-STUTTGART
卷 51, 期 18, 页码 3471-3476出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1611566
关键词
allylation; alkaloids; amino alcohols; diastereoselectivity; asymmetric synthesis; cyclization
资金
- Yonsung Fine Chemicals Co., Ltd.
Total syntheses of (-)-7-epi-alexine and (+)-alexine were achieved by using stereoselective allylation via a functionalized pyrrolidine obtained from an extended chiral 1,3-oxazine. The synthetic strategies include pyrrolidine formation via oxazine cleavage and diastereoselective allylations of a pyrrolidine aldehyde. (-)-7-epi-Alexine and (+)-alexine were synthesized from anti syn anti-oxazine in 12 steps.
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