期刊
SYNTHESIS-STUTTGART
卷 51, 期 20, 页码 3765-3783出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1611863
关键词
tetrazole; [3+2] cycloaddition; heterogeneous catalysis; synthetic methods; medicinal chemistry
资金
- University of Delhi
- DST Purse Grant
Tetrazoles are synthetic organic heterocyclic compounds comprising of high nitrogen content among stable heterocycles. Tetrazoles, chiefly 5-substituted 1 H -tetrazoles have been used as a bioisosteric replacement for carboxylic acids in medicinal chemistry. Various clinical drugs, including losartan, cefazolin, and alfentanil, contain the tetrazole moiety. There have been significant developments in the synthesis of 5-substituted 1 H -tetrazoles. Researchers are still working to develop more efficient and ecofriendly methods for their synthesis. In this review, we provide a comprehensive discussion of the recent advancements in the field of synthesis of 5-substituted 1 H -tetrazoles. 1 Introduction 2 The Role of 5-Substituted 1 H -Tetrazoles in Medicinal Chemistry 3 Synthesis of 5-Substituted 1 H -Tetrazoles 3.1 Microwave-Assisted Synthesis 3.2 Heterogeneous Catalysts 3.3 Nanoparticles as Heterogeneous Catalysts 3.4 Miscellaneous Methods 4 Sartans: A Class of Tetrazole-Based Commercial Drugs 5 Conclusions
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