期刊
STEM CELL REVIEWS AND REPORTS
卷 15, 期 5, 页码 664-679出版社
SPRINGER
DOI: 10.1007/s12015-019-09893-4
关键词
GelMA hydrogel; Synthetic process of regulation; Incorporation of biomaterials; Cell-loaded GelMA scaffold transplantation; Tissue repair
资金
- National Natural Science Foundation of China [81401011, 81572229, 81673777]
- Natural Science Foundation of Zhejiang, China [LY15H060004]
Gelatin methacrylate (GelMA)-based hydrogels are gaining a great deal of attention as potentially implantable materials in tissue engineering applications because of their biofunctionality and mechanical tenability. Since different natural tissues respond differently to mechanical stresses, an ideal implanted material would closely match the mechanical properties of the target tissue. In this regard, applications employing GelMA hydrogels are currently limited by the low mechanical strength and biocompatibility of GelMA. Therefore, this review focuses on modifications made to GelMA hydrogels to make them more suitable for tissue engineering applications. A large number of reports detail rational synthetic processes for GelMA or describe the incorporation of various biomaterials into GelMA hydrogels to tune their various properties, e.g., physical strength, chemical properties, conductivity, and porosity, and to promote cell loading and accelerate tissue repair. A novel strategy for repairing tissue injuries, based on the transplantation of cell-loaded GelMA scaffolds, is examined and its advantages and challenges are summarized. GelMA-cell combinations play a critical and pioneering role in this process and could potentially accelerate the development of clinically relevant applications.
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