期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 288, 期 -, 页码 12-19出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2019.02.083
关键词
Metal organic frameworks; Glucose oxidase; Long period grating; Biosensor
资金
- National Key R&D Program of China [2018YFF01012000]
- National Natural Science Foundation of China [61805016, 61735002]
- Research Fund from Beijing Innovation Center for Future Chips
- Key Cultivation Projects of Beijing Information Science and Technology University [5211823208]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_16R07]
Metal organic frameworks (MOFs) have applied as promising vectors for encapsulating enzymes due to their porous structures. Glucose oxidase (GOx) encapsulated zeolitic imidazole-based metal organic frameworks (ZIF-8) were integrated, with long period grating (LPG) to develop highly stable, label-free optical fiber biosensors. Various morphologies of ZIF-8/GOx composites were synthetized with different concentrations of GOx, Zn2+ and 2-methylimidazole (2-MIM) in precursor solutions. The composites can achieve high protein encapsulation efficiency and show high activity and stability under harsh conditions. In the optical biosensing system, the ZIF-8( Zn-based MOF) acts not only as a protective shell for GOx but also as an analyte collector on fibers. The wavelength shifts are linearly corelated with glucose concentrations in range of 1-8 mM with a response coefficient of (similar to)0.5 nm/mM. The ZIF-8/GOx shows high stability under harsh conditions that would decompose free GOx.
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