期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 98, 期 -, 页码 211-223出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2019.05.025
关键词
Aerobic mitochondrial energy metabolism; Oxidative phosphorylation complex; Antibiotic; Antidiabetic; Chemotherapeutic
资金
- European Union [H2020-MSCA-ITN-2016-722605]
- Austrian Science Fund [P 31228-B33]
- Children's Cancer Foundation Salzburg, Austria
- Vereinigung zur Forderung Padiatrischer Forschung und Fortbildung Salzburg, Austria
Although we have entered the era of personalized medicine and tailored therapies, drugs that target a large variety of cancers regardless of individual patient differences would be a major advance nonetheless. This review article summarizes current concepts and therapeutic opportunities in the area of targeting aerobic mitochondrial energy metabolism in cancer. Old drugs previously used for diseases other than cancer, such as antibiotics and antidiabetics, have the potential to inhibit the growth of various tumor entities. Many drugs are reported to influence mitochondrial metabolism. However, here we consider only those drugs which predominantly inhibit oxidative phosphorylation.
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