期刊
SEMINARS IN CANCER BIOLOGY
卷 62, 期 -, 页码 9-19出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2019.07.007
关键词
HAS2; HAS2-AS1; CD44; 4-Methylumbelliferone; Extracellular matrix
类别
资金
- Universita degli Studi dell'Insubria
- Matex Lab
- RS Regione Lombardia, University of Insubria FAR
- EU H2020 Marie Sklodowska-Curie Grant [645,756]
Extracellular matrix (ECM) is a complex network of macromolecules such as proteoglycans (PGs), glycosaminoglycans (GAGs) and fibrous proteins present within all tissues and organs. The main role of ECM is not only to provide an essential mechanical scaffold for the cells but also to mediate crucial biochemical cues that are required for tissue homeostasis. Dysregulations in ECM deposition alter cell microenvironment, triggering the onset or the rapid progression of several diseases, including cancer. Hyaluronan (HA) is a ubiquitous component of ECM considered as one of the main players of cancer initiation and progression. This review discusses how HA participate in and regulate several aspects of tumorigenesis, with particular attention to the hallmarks of cancer proposed by Hanahan and Weinberg such as sustaining of the proliferative signaling, evasion of apoptosis, angiogenesis, activation of invasion and metastases, reprogramming of energy metabolism and evasion of immune response.
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