期刊
SEMINARS IN CANCER BIOLOGY
卷 64, 期 -, 页码 1-12出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2019.06.001
关键词
Antibody therapeutics; Immunoregulation; Cancer; Autoimmune disease; IL-7R
类别
资金
- National Cancer Center Research and Development Fund [23B-21, 26-A-12, 27-S-5, 29-S-1, 30-S-4]
- JSPS KAKENHI [15H04316, 18H02702]
- Practical Research for Innovative Cancer Control from the Japan Agency for Medical Research and Development, AMED [16ck0106114, 18ck0106407, 18cm0106240, JP19lm0203023]
- Project Mirai Cancer Research Grants
- Princes Takamatsu Cancer Research Fund
- Japan Leukemia Research Fund
- Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics
- Grants-in-Aid for Scientific Research [18H02702, 15H04316] Funding Source: KAKEN
Cancer and autoimmune disease are closely related, and many therapeutic antibodies are widely used in clinics for the treatment of both diseases. Among them, the anti-CD20 antibody has proven to be effective against both lymphoid malignancy and autoimmune disease. Moreover, immune checkpoint blockade using the anti-PD1/PDL1/CTLA4 antibody has improved the prognosis of patients with refractory solid tumors. At the same time, however, over-enhancement of immunoreaction can induce autoimmune reaction. Although anti-TNF antibody therapies represent a breakthrough in the treatment of autoimmune diseases, optimal management is required to control the serious associated issues, including development and progression of cancer, and it is becoming more and more important to control the immunoreaction. In addition, next-generation antibody therapeutics such as antibody-drug conjugates and bispecific antibodies, are anticipated to treat uncontrolled cancer and autoimmune disease. IL-7R signaling plays an important role in the development and progression of both lymphoid malignancy and autoimmune disease. In addition, abnormal homing activity and steroid resistance caused by IL7R signaling may worsen prognosis. Therefore, anti-IL-7R targeting antibody therapies that enable suppression of such pathophysiological status have the potential to be beneficial for the treatment of both diseases. In this review, we discuss current antibody therapeutics in cancer and autoimmune disease, and describe a new therapeutic strategy for immunoregulation including IL-7R targeting antibodies.
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