Sucrosomial® iron and folic acid supplementation is able to induce Il-6 levels variation in healthy trained professional athletes, regardless of the hemoglobin and iron values

Objective. - Inflammation plays a fundamental role in the healing process after a trauma. Recent data have suggested that interleukin-6 (IL-6) plays a key role in iron metabolism after stress response. Equipment and methods. - To study the correlation between iron metabolism and inflammatory status in fifteen professional male athletes, a Sucrosomial((R)) iron plus folic acid supplement was administered during the professional sport season and a prospective analysis of data was performed. Results. - The healthy athletes who took the supplement did not show a significant increase in hemoglobin or iron parameters, compared to those who did not receive it. However, none of them started from deficit conditions. Interestingly, the athletes who received Sucrosomial((R)) iron had a significant lower IL-6 levels throughout the season (4.22 +/- 3.7 pg/ml vs 6.9 +/- 9.6 pg/ml, P = 0.04 and 6.3 +/- 3.1 pg/ml vs 11.1 +/- 7.7 pg/ml, P = 0.04). This is the first demonstration that Sucrosomial((R)) iron plus folic acid supplementation in professional athletes is able to induce IL-6 levels variation during the season, regardless of the values of hemoglobin and serum iron. (C) 2019 L'Auteur(s). Publie par Elsevier Masson SAS.