期刊
SCIENCE
卷 364, 期 6445, 页码 1082-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aax0758
关键词
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资金
- Sir Henry Wellcome Postdoctoral Fellowship
- EMBO Postdoctoral Fellowship [ALTF 120-2017]
- FAPESP [2017/03729-2]
- NIH [MH107396, NS074015, U19NS104590]
- NSF [1707316]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/03729-2] Funding Source: FAPESP
Hippocampal sharp wave ripples (SPW-Rs) have been hypothesized as a mechanism for memory consolidation and action planning. The duration of ripples shows a skewed distribution with a minority of long-duration events. We discovered that long-duration ripples are increased in situations demanding memory in rats. Prolongation of spontaneously occurring ripples by optogenetic stimulation, but not randomly induced ripples, increased memory during maze learning. The neuronal content of randomly induced ripples was similar to short-duration spontaneous ripples and contained little spatial information. The spike content of the optogenetically prolonged ripples was biased by the ongoing, naturally initiated neuronal sequences. Prolonged ripples recruited new neurons that represented either arm of the maze. Long-duration hippocampal SPW-Rs replaying large parts of planned routes are critical for memory.
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