期刊
SCIENCE
卷 364, 期 6446, 页码 1153-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aav6335
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资金
- National Natural Science Foundation of China [31822052, 31572381]
- National Thousand Youth Talents Plan
- Talents Team Construction Fund of Northwestern Polytechnical University (NWPU)
- National Program for Support of Top-notch Young Professionals
- Strategic Priority Research Program of CAS [XDB13000000, XDA16010405]
- 1000 Talent Project of Shaanxi Province
- Villum Foundation Young Investigator grant [VKR023447]
- Natural Science Foundation of China [31501984]
- Natural Science Foundation of Jilin Province [20170101158JC]
- Central Public-Interest Scientific Institution Basal Research Fund [Y2019GH13]
Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis.
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