期刊
SCHIZOPHRENIA RESEARCH
卷 210, 期 -, 页码 21-29出版社
ELSEVIER
DOI: 10.1016/j.schres.2019.06.014
关键词
Neurocognition; Cognitive impairment; Unaffected relatives; Schizophrenia; Bipolar disorder; Endophenotypes
类别
资金
- Instituto de Salud Carlos III [PI16/1770, PROMETEOII/2015/021]
- Generalitat Valenciana [PI17/00719]
- ISCIII-FEDER
Although there is substantial evidence supporting the existence of neurocognitive impairment in patients diagnosed with schizophrenia (SZ) and bipolar disorder (BD), few studies have explored the field from an endophenotypic perspective. The present systematic review sought to identify longitudinal family studies exploring suitable neurocognitive endophenotypes in unaffected relatives of patients with SZ and/or BD. Following the PRISMA statement, only five follow-up studies met the inclusion criteria, comprising 79 SZ patients, 159 SZ unaffected relatives of SZ, 131 BD patients, 77 unaffected relatives of BD, and 248 controls. Verbal memory, auditory attention, face memory and emotion processing were found as putative endophenotypic candidates for SZ, whereas this strategy identified none for BD. Substantial heterogeneity and lack of standardization in global neurocognitive assessment within this area should be pointed out; nevertheless, several candidate endophenotypes were identified for SZ, except for executive impairment. (C) 2019 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据