N-Propargyltetrahydrocarbazoles and N-propargyltetrahydro-γ-carbolines in 1,3-cycloaddition with azide-containing pharmacophores

A modification of tetrahydrocarbazoles and tetrahydro-gamma-carbolines with pharmacophore ligands was performed based on the copper-catalyzed 1,3-dipolar cycloaddition of their N-propargyl derivatives to azide-containing carbazoles, tetrahydrocarbazoles, 1-aminoadamantanes, and phenothiazine.