期刊
RUSSIAN CHEMICAL BULLETIN
卷 68, 期 5, 页码 1000-1005出版社
SPRINGER
DOI: 10.1007/s11172-019-2510-7
关键词
1H-benzimidazoles; sterically hindered phenols; isobornylphenols; antioxidant activity; membrane-protective activity; red blood cells; oxidative hemolysis
资金
- Ministry of Science and Higher Education of the Russian Federation [AAAA-A18-118012490385-8, AAAA-A18-118011120004-5]
A series of new 2-substituted-1H-benzimidazoles was synthesized on the basis of 4-hydroxybenzaldehydes. Their antioxidant properties were evaluated in the in vitro models and compared with those of known analogs. The structural specifi c features of the molecules responsible for the high antioxidant activity were revealed. Among tested derivatives, 2-substituted 1H-benzimidazole containing a phenol fragment with isobornyl and tert-butyl groups was found to have the greatest ability to protect biomolecules and cells under conditions of acute oxidative stress.
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