期刊
RESPIROLOGY
卷 25, 期 4, 页码 393-400出版社
WILEY
DOI: 10.1111/resp.13651
关键词
bronchodilator-naive; chronic obstructive pulmonary disease; glycopyrronium; indacaterol-glycopyrronium combination; tiotropium
资金
- MRC [G1001365, G1001372, G0800570] Funding Source: UKRI
- Medical Research Council [G1001365, G1001372, G0800570] Funding Source: Medline
- Novartis Pharma Funding Source: Medline
- Department of Health [RP-PG-0109-10056] Funding Source: Medline
Background and objective Indacaterol/glycopyrronium (IND/GLY) 110/50 mu g once daily (q.d.) has demonstrated greater improvements in lung function, patient-reported outcomes and lower exacerbation rates versus mono long-acting muscarinic antagonists (LAMA) in chronic obstructive pulmonary disease (COPD) patients. However, data are limited on initial treatment with IND/GLY 110/50 mu g q.d. versus mono LAMA in COPD patients, not previously on maintenance treatment with long-acting bronchodilators (LABD). Methods A pooled analysis of ARISE, SHINE and SPARK trials was conducted to evaluate the efficacy of IND/GLY 110/50 mu g q.d. versus open-label (OL) tiotropium (TIO) 18 mu g q.d. and GLY 50 mu g q.d. in COPD patients, not on maintenance treatment with LABD at study entry (LABD-naive). Efficacy was assessed after 24/26 weeks of treatment. Results In total, 998 LABD-naive patients were included (IND/GLY: 353; OL TIO: 328; GLY: 317). Patients treated with IND/GLY 110/50 mu g q.d. experienced greater improvements in trough forced expiratory volume in 1 s (FEV1) versus OL TIO 18 mu g q.d. (least squares mean treatment difference (Delta): 0.086 L) and GLY 50 mu g q.d. (Delta: 0.080 L) after 24/26 weeks. Improvements in electronic diary (eDiary) symptom scores, transition dyspnoea index (TDI) focal score, St George's Respiratory Questionnaire (SGRQ) total score and rescue medication use were also greater with IND/GLY versus OL TIO and GLY. Greater proportion of patients achieved minimal clinically important difference in trough FEV1, TDI and SGRQ with IND/GLY versus OL TIO and GLY. Conclusion LABD-naive patients treated with IND/GLY 110/50 mu g q.d. achieved improvements in lung function, daily symptoms, dyspnoea, health-related quality of life and rescue medication use versus those who received single LAMA.
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