期刊
AQUATIC TOXICOLOGY
卷 180, 期 -, 页码 258-265出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aquatox.2016.10.010
关键词
Quaternium-15; Cytotoxicity; Haemolymphatic parameters; Oxidative stress; Mytilus galloprovincialis
The presence of a xenobiotic in the environment can often represent a risk for living organisms. Quaternium-15, a preservative, is one of the most used substances and is added to several cosmetics and other industrial products. For this reason,kwowing the bio-indicator of the marine environment, the toxicological effects potentially elicited by this preservative on the marine invertebrate Mytilus gallo-provincialis were studied. The results of this work confirm that quaternium-15, used at 0.1 and 1 mg/l concentrations, while metabolized in M. galloprovincialis, causes a decrease in cellular viability, and remarkable changes to the defense and antioxidant system. In fact, haemocyte viability is dramatically reduced, and haemolymphatic parameter measurements indicate a stress on the animal. Moreover, an increase in radical species production, in Thiobarbituric Acid Reactive Species (TBARS) concentration, and in the Heat Shock Protein 70 amount, were observed in hepatopancreas. These changes suggest that the antioxidant systems are activated to overwhelm the oxidative damage induced by quaternium-15. Quaternium-15 jeopardizes both the defense and antioxidant systems. These results provide essential information with the biological fate of quaternium-15 in aquatic organisms, and confirm that biomarkers represent an important tool for modern environmental assessments as they can help with the prediction of pollutants involved in the monitoring program. (C) 2016 Elsevier B.V. All rights reserved.
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