期刊
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK
卷 60, 期 2, 页码 147-156出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/bmt-2014-0101
关键词
ablation; cardiac arrhythmia; hadron therapy; moving organs; noninvasive interventions; treatment planning
资金
- German Research Foundation (DFG) as part of the Clinical Research Group (KFO) [214/2]
- Helmholtz Association
Hadron therapy has already proven to be successful in cancer therapy, and might be a noninvasive alternative for the ablation of cardiac arrhythmias in humans. We present a pilot experiment investigating acute effects of a C-12 irradiation on the AV nodes of porcine hearts in a Langendorff setup. This setup was adapted to the requirements of charged particle therapy. Treatment plans were computed on calibrated CTs of the hearts. Irradiation was applied in units of 5 and 10 Gy over a period of about 3 h until a total dose of up to 160 Gy was reached. Repeated application of the same irradiation field helped to mitigate motion artifacts in the resulting dose distribution. After irradiation, PET scans were performed to verify accurate dose application. Acute AV blocks were identified. No other acute effects were observed. Hearts were kept in sinus rhythm for up to 6 h in the Langendorff setup. We demonstrated that C-12 ions can be used to select a small target in the heart and, thereby, influence the electrical conduction system. Second, our pilot study seems to suggest that no adverse effects have to be expected immediately during heavy ion irradiation in performing subsequent experiments with doses of 30-60 Gy and intact pigs.
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