期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 26, 期 -, 页码 342-349出版社
ELSEVIER
DOI: 10.1016/j.pdpdt.2019.04.019
关键词
Hydrophobic carbon quantum dots; Medical grade polydimethylsiloxane; Antibacterial surfaces; Visible light sterilization; Antimicrobial photodynamic Therapy
类别
资金
- SASPRO Programme [1237/02/02-b]
- People Programme (Marie Curie Actions) European Union's Seventh Framework Programme under REA [609427]
- VEGA [2/0093/16]
- Ministry of Education, Youth and Sports of the Czech Republic Program NPU I [LO1504]
- Czech Science Foundation [19-09721S]
- Ministry of Education, Science and Technological Development of the Republic of Serbia [172003]
- bilateral project Serbia-Slovakia [SK-SRB-2016-0038]
- multilateral scientific and technological cooperation in the Danube region [DS-2016-021]
Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation.
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