4.6 Review

Tissue mechanics, an important regulator of development and disease

出版社

ROYAL SOC
DOI: 10.1098/rstb.2018.0215

关键词

mechanobiology; microenvironment; tissue mechanics; extracellular matrix; cancer

类别

资金

  1. National Institute of Health [U01CA202241-01]
  2. Department of Defense-BCRP, USMRAA [BC122990]
  3. California Institute of Regenerative Medicine [RB5-07409]
  4. UC Berkeley-UCSF Graduate Program in Bioengineering
  5. Schlumberger Foundation Faculty for the Future program
  6. CDMRP [BC122990, 542337] Funding Source: Federal RePORTER

向作者/读者索取更多资源

A growing body of work describes how physical forces in and around cells affect their growth, proliferation, migration, function and differentiation into specialized types. How cells receive and respond biochemically to mechanical signals is a process termed mechanotransduction. Disease may arise if a disruption occurs within this mechanism of sensing and interpreting mechanics. Cancer, cardiovascular diseases and developmental defects, such as during the process of neural tube formation, are linked to changes in cell and tissue mechanics. A breakdown in normal tissue and cellular forces activates mechanosignalling pathways that affect their function and can promote disease progression. The recent advent of high-resolution techniques enables quantitative measurements of mechanical properties of the cell and its extracellular matrix, providing insight into how mechanotransduction is regulated. In this review, we will address the standard methods and new technologies available to properly measure mechanical properties, highlighting the challenges and limitations of probing different length-scales. We will focus on the unique environment present throughout the development and maintenance of the central nervous system and discuss cases where disease, such as brain cancer, arises in response to changes in the mechanical properties of the microenvironment that disrupt homeostasis.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据