期刊
PEDOSPHERE
卷 29, 期 3, 页码 273-282出版社
SCIENCE PRESS
DOI: 10.1016/S1002-0160(18)60062-1
关键词
animal agriculture; antibiotic-resistant bacteria; antimicrobial resistance; aquaculture; human health; One Health framework; soil contamination; wastewater and sludge
类别
资金
- National Natural Science Foundation of China [21677149]
- Outstanding Youth Fund of the Natural Science Foundation of Jiangsu Province, China [BK20150050]
- Innovative Project of Chinese Academy of Sciences [ISSASIP1616]
- Center for Health Impacts of Agriculture (CHIA) of Michigan State University, USA
- Agriculture and Agri-Food Canada
- Canadian Genomics Research Development Initiative (GRDI-AMR)
- FCT-Fundacao para a Ciencia e a Tecnologia, Portugal [UID/Multi/50016/2013]
- Collaborative Research Fund of Hong Kong (CRF), China [C6033-14G]
- Canadian Institute for Health Research (CIHR) through the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR)
- Academy of Finland
- Joint Programming Initiative Water Challenges for a Changing World (Water JPI)
- Fundação para a Ciência e a Tecnologia [UID/Multi/50016/2013] Funding Source: FCT
Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components. This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal. Recently, much work has been done describing antibiotic resistance genes in various environments; now quantitative, mechanistic, and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.
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