期刊
PATHOLOGY & ONCOLOGY RESEARCH
卷 26, 期 2, 页码 641-649出版社
FRONTIERS MEDIA SA
DOI: 10.1007/s12253-019-00671-8
关键词
Pancreas; Solid-pseudopapillary neoplasm; Histogenesis; Review
The solid-pseudopapillary neoplasm of the pancreas is a rare but enigmatic entity occurring mainly in young women. Since the first description by V. Frantz in 1959 the terminology of this tumor has continuously changed but it has remained simply descriptive, because the exact histogenesis is still obscure. Although in majority of cases the survival is excellent, nevertheless, the expected prognosis is not exactly predictable. In this review the authors aim to summarize its clinico-pathological features, the expected biological behavior, the molecular alterations, the immune phenotype and discuss the putative histogenesis. From diagnostic point of view, the salient histological characteristic findings are analyzed that would help to differentiate it from other, look-alike pancreatic tumors, and suggestions are made about the desirable content of the histological report.
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