期刊
PARASITOLOGY
卷 146, 期 12, 页码 1571-1577出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0031182019000878
关键词
Arteether; cerebral malaria; glutamate; NMDA receptor; Plasmodium berghei ANKA
类别
资金
- CSIR [GAP0147]
- ICMR
- UGC
Cerebral malaria (CM) is the severe neurological complication causing acute non-traumatic encephalopathy in tropical countries. The mechanisms underlying the fatal cerebral complications are still not fully understood. Glutamate, a major excitatory neurotransmitter in the central nervous system of the mammalian brain, plays a key role in the development of neuronal cells, motor function, synaptic plasticity, learning and memory processes under normal physiological conditions. The subtypes of ionotropic glutamate receptor are N-methyl-D-aspartate receptors (NMDARs) which are involved in cellular mechanisms of learning and memory, synaptic plasticity and also mediate excitotoxic neuronal injury. In the present study, we found that glutamate level in synaptosomes, as well as expression of NMDAR, was elevated during the extreme condition of CM in C57BL6 mice. Arteether at 50 mg kg(-1) x 1, 25 mg kg(-1) x 2, days decreased the NMDAR expression and increased the overall survival of the experimental CM mice.
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