期刊
ORGANIC LETTERS
卷 21, 期 15, 页码 5779-5783出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01440
关键词
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资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2017R1D1A1B03028172]
- US National Cancer Institute (NIH) [R37 CA044848]
Meroterpenoids, meroindenon (1) and merochlorins E (2) and F (3), were isolated from a marine-derived bacterium belonging to the genus Streptomyces. Their chemical structures were established using extensive analysis of MS, UV, ECD, and NMR spectroscopic data. Compounds 1-3 possess a tetrahydroxynaphthalene core and a C-15-isoprene unit. Compounds 2 and 3 exhibited strong antibacterial activities against B. subtilis, K. rhizophila, and S. aureus, with a range of MIC values from 1 to 2 mu g/mL.
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