期刊
ORGANIC LETTERS
卷 21, 期 13, 页码 5172-5177出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01769
关键词
-
资金
- United States National Institutes of Health, Institute of General Medical Sciences [R01GM116987]
- University of North Carolina at Chapel Hill
A single-pot Cu-catalyzed enantio- and diaster-eoselective tandem hydroboration/borylative cyclization of alkynes with ketones for the synthesis of carbocycles is reported. The reaction proceeds via desymmetrization and generates four contiguous stereocenters, including an all-carbon quaternary center. The method provides rapid access to [6,5]- and [5,5]-bicycles and cyclopentane products. Catalyst-controlled diastereoselectivity by selection of bisphosphine ligand is noted. Utility of the products is demonstrated by site- and chemoselective transformations that afford valuable alkenyl and allyl organoborons.
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