4.8 Article

Acyl Radicals from Benzothiazolines: Synthons for Alkylation, Alkenylation, and Alkynylation Reactions

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ORGANIC LETTERS
卷 21, 期 14, 页码 5462-5466

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01717

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资金

  1. National Natural Science Foundation of China [21425415, 21774056]
  2. National Basic Research Program of China [2015CB856303]
  3. Science and Technology Department of Jiangsu Province [BRA2017360, BK20181255]

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We describe herein a fundamentally new visible light-driven homolytic C-C bond breaking mode for the generation of acyl radicals from C2-aryl-substituted benzothiazolines. The reactive species can be used as versatile synthons for formal radical alkylation, alkenylation, and alkynylation reactions.

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