期刊
ORGANIC LETTERS
卷 21, 期 14, 页码 5660-5664出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01998
关键词
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资金
- National Key Research and Development Program of China [2018YFC0310903]
- Drug Innovation Major Project [2018ZX09711-001-001-009]
- National Natural Science Foundation of China (NSFC) [81520108028, 21672230, 81603022, 41676073]
- NSFC/CNRS joint project [81811530284]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- SKLDR/SIMM Project [SIMM1903ZZ-04]
- Chinese Academy of Sciences [2016258]
- SA-SIBS Scholarship Program
Two novel polyoxygenated diterpenoids, klyflaccilides A (1) and B (2), featuring an uncommon 6/5/8/3 tetracyclic ring system, were isolated from the Hainan soft coral Klyxum flaccidum. Their structures were established by extensive spectroscopic analysis, X-ray diffraction analysis, and/or a quantum chemical computation method. A plausible biosynthetic relationship of 1 and 2 with their potential precursor 3 was further proposed. Compounds 1 and 3 exhibited moderate anti-inflammatory activity by the inhibition of LPS-induced TNF-alpha protein release.
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