期刊
ORGANIC LETTERS
卷 21, 期 14, 页码 5591-5595出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01929
关键词
-
资金
- National Science Foundation [CHE-0922973, CHE-0741793, CHE-1266314, CHE-1665139]
- Calvin College
A new Au(I)-catalyzed method for the preparation of trisubstituted indolizines from easily accessible 2-propargyloxy-pyridines is reported. The reaction tolerates a wide range of functionality, allowing for diversity to be introduced in four distinct regions of the product (R, R-1, R-2, and Ar). The proposed mechanism proceeds via enol addition to an allenamide intermediate and explains the observed increase in yields when electron poor methyl ketones are utilized.
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