期刊
ORGANIC LETTERS
卷 21, 期 12, 页码 4788-4792出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01674
关键词
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资金
- JSPS KAKENHI [Japan Society for the Promotion of Science (JSPS)] [17H05055, 17H05428, 19H04642]
- Naito Foundation
- Astellas Foundation for Research on Metabolic Disorders
- Grants-in-Aid for Scientific Research [17H05055, 17H05428, 19H04642] Funding Source: KAKEN
Heterologous expression of a unique biosynthetic gene cluster (BGC) comprising a highly reducing polyketide synthase and stand-alone thioesterase genes in Aspergillus oryzae enabled us to isolate a novel 34-membered polyene macrolide, phaeospelide A (1). This is the first isolation of a fungal polyene macrolide and the first demonstration of fungal aliphatic macrolide biosynthetic machinery. In addition, sequence similarity network analysis demonstrated the existence of a large number of BGCs for novel fungal macrolides.
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