期刊
ORGANIC LETTERS
卷 21, 期 12, 页码 4480-4485出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01329
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-
资金
- NSFC [21632003, 21871116, 21572087]
- Key Program of Gansu Province [17ZD2GC011]
- 111 Program from the MOE of P. R China
A visible-light-promoted metal-free alkylheteroarylation of unactivated olefins was developed by using readily available ketones/esters as the alkyl radical source. With this strategy, both linear and cyclic ketones/esters could be conveniently converted to corresponding alpha-carbonyl alkyl radical species by using commonly found diacylperoxide (LPO) as the hydrogen atom transfer reagent, and heteroaryl-containing 1,7-carbonyl compounds were synthesized via distal heteroaryl ipso migration in good to excellent yields with high functional group tolerance and a broad substrate scope. In addition, this approach was also amenable to C-H functionalization of acetonitrile, dichloromethane, 1,2-dichloroethane, and chloroform.
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