期刊
NUTRITION JOURNAL
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12937-019-0458-y
关键词
Mild hypoalbuminemia; Postoperative mortality and morbidity; Colorectal cancer; Propensity score matching
BackgroundMalnutrition with hypoalbuminemia (albumin <35g/L) is an important factor in predicting risks associated with colorectal cancer surgery. However, there is limited data about the effects of mild hypoalbuminemia with small decreases in albumin on postoperative complications.MethodsThis is a retrospective study using the multi-institutional, nationally validated database of the American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) to investigate mild hypoalbuminemia and its association with postoperative mortality and morbidity by using a propensity score matching method.ResultsIn a group of 30,676 colorectal cancer patients who received surgery, 5230 had mild hypoalbuminemia (<35 and>=30g/L) and 21,310 had normal albumin levels (>=35g/L). Significant differences were noted in 21 clinical characteristics between the two groups. After 1:2 propensity score matching postoperative mortality was significantly associated with mild hypoalbuminemia (OR=1.74; p<0.001). There were significant associations between mild hypoalbuminemia and 11 postoperative morbidities including deep vein thrombosis, pulmonary embolism, superficial and deep surgical site infection, pneumonia, septic shock, ventilator>48h, blood transfusion, return to operating room, stroke and re-intubation. Mild hypoalbuminemia was also associated with overall complication (B=0.064, p<0.001) and length of total hospital stay (B=2.236, p<0.001).ConclusionsIn colorectal cancer, this is the first propensity score matching study of malnutrition with mild hypoalbuminemia which demonstrates that a mild decrease in serum albumin contributes significantly to poor postoperative outcome.
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