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Motivation and cognitive control in depression

期刊

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 102, 期 -, 页码 371-381

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2019.04.011

关键词

Depression; Cognitive control; Anhedonia; Motivation; Reward anticipation; Effort; Controllability of environment

资金

  1. Special Research Fund (BOF) of Ghent University [01D02415]
  2. Center of Biomedical Research Excellence grant from the National Institute of General Medical Sciences [P20GM103645]
  3. European Research Council (ERC) [636116]
  4. Concerted Research Action Grant of Ghent University [BOF16/GOA/017]
  5. John Templeton Foundation

向作者/读者索取更多资源

Depression is linked to deficits in cognitive control and a host of other cognitive impairments arise as a consequence of these deficits. Despite of their important role in depression, there are no mechanistic models of cognitive control deficits in depression. In this paper we propose how these deficits can emerge from the interaction between motivational and cognitive processes. We review depression-related impairments in key components of motivation along with new cognitive neuroscience models that focus on the role of motivation in the decision-making about cognitive control allocation. Based on this review we propose a unifying framework which connects motivational and cognitive control deficits in depression. This framework is rooted in computational models of cognitive control and offers a mechanistic understanding of cognitive control deficits in depression.

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