期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 105, 期 -, 页码 126-133出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2019.07.017
关键词
Zebrafish; Rodent models; Schizophrenia; Positive symptoms; Negative symptoms; Translational research
资金
- Russian Science Foundation [19-15-00053]
- President of Russia PhD Fellowship
- Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC)
- Rector's Special Productivity Fellowship
- Russian Science Foundation [19-15-00053] Funding Source: Russian Science Foundation
Schizophrenia is a severely debilitating, lifelong psychiatric disorder affecting approximately 1% of global population. The pathobiology of schizophrenia remains poorly understood, necessitating further translational research in this field. Experimental (animal) models are becoming indispensable for studying schizophrenia-related phenotypes and pro/antipsychotic drugs. Mounting evidence suggests the zebrafish (Danio rerio) as a useful tool to model various phenotypes relevant to schizophrenia. In addition to their complex robust behaviors, zebrafish possess high genetic and physiological homology to humans, and are also sensitive to drugs known to reduce or promote schizophrenia clinically. Here, we summarize findings on zebrafish application to modeling schizophrenia, as well as discuss recent progress and remaining challenges in this field. We also emphasize the need in further development and wider use of zebrafish models for schizophrenia to better understand its pathogenesis and enhance the search for new effective antipsychotics.
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