期刊
NEURON
卷 103, 期 5, 页码 865-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2019.06.006
关键词
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资金
- NIH-NINDS (National Institute of Neurological Disorders and Stroke) [K01 K01NS094545, R01 1R01NS110713, R01 NS103905]
- McKnight Foundation
- Whitehall Foundation
- Alice and Joseph Brooks postdoctoral fellowship
- Edward R. and Anne G. Lefler Center postdoctoral fellowship
The ability of neurons to identify correct synaptic partners is fundamental to the proper assembly and function of neural circuits. Relative to other steps in circuit formation such as axon guidance, our knowledge of how synaptic partner selection is regulated is severely limited. Drosophila Dpr and DIP immunoglobulin superfamily (IgSF) cell-surface proteins bind heterophilically and are expressed in a complementary manner between synaptic partners in the visual system. Here, we show that in the lamina, DIP misexpression is sufficient to promote synapse formation with Dpr-expressing neurons and that disrupting DIP function results in ectopic synapse formation. These findings indicate that DIP proteins promote synapses to form between specific cell types and that in their absence, neurons synapse with alternative partners. We propose that neurons have the capacity to synapse with a broad range of cell types and that synaptic specificity is achieved by establishing a preference for specific partners.
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