期刊
NATURE NEUROSCIENCE
卷 22, 期 7, 页码 1110-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41593-019-0408-1
关键词
-
资金
- National Institutes of Health (NIDA) [F32-DA041184, R01-DA032750, R01-DA038168]
- National Institutes of Health (NIMH) [F32-MH113327]
- Brain and Behavior Research Foundation (NARSAD Independent Investigator Award)
- NARSAD Young Investigator Award
- Yang Family Biomedical Scholars Award
- UNC Neuroscience Center (Helen Lyng White Fellowship)
- UNC Neuroscience Center Microscopy Core [P30 NS045892]
- UNC Department of Psychiatry
- Foundation of Hope
Learning to predict rewards based on environmental cues is essential for survival. The orbitofrontal cortex (OFC) contributes to such learning by conveying reward-related information to brain areas such as the ventral tegmental area (VTA). Despite this, how cue-reward memory representations form in individual OFC neurons and are modified based on new information is unknown. To address this, using in vivo two-photon calcium imaging in mice, we tracked the response evolution of thousands of OFC output neurons, including those projecting to VTA, through multiple days and stages of cue-reward learning. Collectively, we show that OFC contains several functional clusters of neurons distinctly encoding cue-reward memory representations, with only select responses routed downstream to VTA. Unexpectedly, these representations were stably maintained by the same neurons even after extinction of the cue-reward pairing, and supported behavioral learning and memory. Thus, OFC neuronal activity represents a long-term cue-reward associative memory to support behavioral adaptation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据