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Flavia Niccolini et al.
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Ryan G. Lim et al.
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Krystof S. Bankiewicz et al.
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Fatima Lopes et al.
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Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers
Heather Wilson et al.
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Carmen Agustin-Pavon et al.
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Pratiksha I. Thakore et al.
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Eduardo E. Arteaga-Bracho et al.
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David S. Russell et al.
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Guohao Wang et al.
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Virginia B. Mattis et al.
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Tim Indersmitten et al.
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Monica Banez-Coronel et al.
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Elizabeth Hinde et al.
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Gillian P. Bates et al.
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Charles A. Gersbach et al.
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Amber L. Southwell et al.
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Nan Wang et al.
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Matthias Minderer et al.
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Holly B. Kordasiewicz et al.
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Mireia Garriga-Canut et al.
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Christopher A. Ross et al.
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Sarah A. Plautz et al.
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Ryan L. Boudreau et al.
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John Morlan et al.
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Jens Boch et al.
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SQ Harper et al.
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Enhanced allele-specliflic PCR discriminationin SNP genotypling using 3′ locked nucleic acid (LNA) primers
D Latorra et al.
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F Trettel et al.
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Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
I Dragatsis et al.
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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
A Yamamoto et al.
CELL (2000)
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