期刊
NATURE IMMUNOLOGY
卷 20, 期 9, 页码 1129-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-019-0448-4
关键词
-
类别
资金
- Pathogenesis Program of the Heinrich Pette Institute
- Viral Latency Program of the Heinrich Pette Institute
- Leibniz Institute for Experimental Virology
- German Center for Infection Research (DZIF) [TTU 04.810, TI 07.002]
- Frederick National Laboratory for Cancer Research [HHSN261200800001E]
- Intramural Research Program of the National Institutes of Health, Frederick National Laboratory, Center for Cancer Research
- National Institute of General Medical Sciences [T32GM007752]
- NIH [P01-AI104715, F31AI116366, U19 NS095774]
- Australian Research Council Laureate Fellowship [FL160100049]
- National Health and Medical Research Council of Australia [APP1109901]
- German Center for Infection Research (DZIF) via the Clinician Scientist Program of the Faculty of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Natural killer (NK) cells can recognize virus-infected and stressed cells(1) using activating and inhibitory receptors, many of which interact with HLA class I. Although early studies also suggested a functional impact of HLA class II on NK cell activity(2,3), the NK cell receptors that specifically recognize HLA class II molecules have never been identified. We investigated whether two major families of NK cell receptors, killer-cell immunoglobulin-like receptors (KIRs) and natural cytotoxicity receptors (NCRs), contained receptors that bound to HLA class II, and identified a direct interaction between the NK cell receptor NKp44 and a subset of HLA-DP molecules, including HLA-DP401, one of the most frequent class II allotypes in white populations(4). Using NKp444 zeta(+) reporter cells and primary human NKp44(+) NK cells, we demonstrated that interactions between NKp44 and HLA-DP401 trigger functional NK cell responses. This interaction between a subset of HLA-DP molecules and NKp44 implicates HLA class II as a component of the innate immune response, much like HLA class I. It also provides a potential mechanism for the described associations between HLA-DP subtypes and several disease outcomes, including hepatitis B virus infection(5-7), graft-versus-host diseases and inflammatory bowel disease(9,10).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据