期刊
NATURE GENETICS
卷 51, 期 7, 页码 1099-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41588-019-0425-8
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资金
- US Department of Agriculture US Wheat and Barley Scab Initiative
- National Research Initiative competitive grants from the USDA National Institute of Food and Agriculture [2017-67007-25939, 2017-67007-25929]
- NIFA [914496, 2017-67007-25929] Funding Source: Federal RePORTER
Fusarium head blight (FHB), which is mainly caused by Fusarium graminearum, is a destructive wheat disease that threatens global wheat production. Fhb1, a quantitative trait locus discovered in Chinese germplasm, provides the most stable and the largest effect on FHB resistance in wheat. Here we show that TaHRC, a gene that encodes a putative histidine-rich calcium-binding protein, is the key determinant of Fhb1-mediated resistance to FHB. We demonstrate that TaHRC encodes a nuclear protein conferring FHB susceptibility and that a deletion spanning the start codon of this gene results in FHB resistance. Identical sequences of the TaHRC-R allele in diverse accessions indicate that Fhb1 had a single origin, and phylogenetic and haplotype analyses suggest that the TaHRC-R allele most likely originated from a line carrying the Dahongpao haplotype. This discovery opens a new avenue to improve FHB resistance in wheat, and possibly in other cereal crops, by manipulating TaHRC sequence through bioengineering approaches.
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