期刊
NATURE CHEMICAL BIOLOGY
卷 15, 期 8, 页码 803-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41589-019-0311-9
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资金
- German Research Foundation (DFG) through the Research Unit FOR2406 'Proteogenomics of Marine Polysaccharide Utilization' (POMPU) [BO 1862/17-1, HE 7217/2-1, SCHW 595/10-1]
- DFG [HE 7217/1-1]
- French National Research Agency (ANR) [ANR-10-BTBR-04, ANR-14-CE19-0020-01]
- Institute of Marine Biotechnology e.V.
Marine seaweeds increasingly grow into extensive algal blooms, which are detrimental to coastal ecosystems, tourism and aquaculture. However, algal biomass is also emerging as a sustainable raw material for the bioeconomy. The potential exploitation of algae is hindered by our limited knowledge of the microbial pathways-and hence the distinct biochemical functions of the enzymes involved-that convert algal polysaccharides into oligo- and monosaccharides. Understanding these processes would be essential, however, for applications such as the fermentation of algal biomass into bioethanol or other value-added compounds. Here, we describe the metabolic pathway that enables the marine flavobacterium Formosa agariphila to degrade ulvan, the main cell wall polysaccharide of bloom-forming Ulva species. The pathway involves 12 biochemically characterized carbohydrate-active enzymes, including two polysaccharide lyases, three sulfatases and seven glycoside hydrolases that sequentially break down ulvan into fermentable monosaccharides. This way, the enzymes turn a previously unexploited renewable into a valuable and ecologically sustainable bioresource.
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