期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 6, 页码 1035-1037出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1613400
关键词
Antidiabetic activity; high performance liquid chromatography; Momordica charantia Linn (MC)
资金
- National Medicinal Plant Board, Ministry of Ayush [Z.18017/187/CSS/R&D/MH-01/2015-16-NMPB]
The dry powder of MC fruits was extracted using various methods to obtain two phytoconstituents, one of which exhibited potent alpha-amylase inhibitory activity, reported for the first time.
The dry powder of MC fruits was extracted by maceration, ultrasonication, liquid-liquid partition and soxhlation. The in vitro antidiabetic and antioxidant assays were used to screen extracts and fractions. Refluxed and liquid partitioned extracts were fractionated using petroleum ether and ethyl acetate and purified with the help of preparative HPLC to give 2 phytoconstituents M1 and M2 respectively. Compound M1 (1) was identified as charantin and Compound M2 (2) was identified as momordicinin using spectral studies. Momordicinin showed potent alpha-amylase inhibitory activity with IC50 15.86 mu g/ml which was reported for the first time. [GRAPHICS] .
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