期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 8, 页码 1323-1330出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1647426
关键词
Astragalus dolichochaete; Leguminosae; isoflavanes; flavanones; structural elucidation; cytotoxicity
资金
- National Natural Science Foundation of China [31170313, 81460532]
- Innovation Team Project of Dali University for Development and Utilization of Characteristic Medicinal Plants in Western Yunnan & Bai Nationality Medicines [ZKLX2019106]
The study revealed significant cytotoxicity of Astragalus dolichochaete and isolated two new compounds with cytotoxic activities. These compounds showed significant cytotoxicity in human cancer cell lines.
Astragali Radix (Huangqi) is one of the well-known traditional Chinese medicines and has been used in China for more than two thousand years. As a close species, Astragalus dolichochaete Diels was found to possess cytotoxicity during our preliminary study of Astragalus plants from Yunnan Province, China. To better understand the chemical foundation of the cytotoxicity, the major constituents of A. dolichochaete were studied. As a result, two new 8-isopentenyl isoflavane derivatives, dolichochaeteins A and B (1 and 2), together with ten known constituents were isolated, and their structures were elucidated by means of spectroscopy, mainly 1D and 2D NMR techniques. The cytotoxic activities were evaluated for the raw extract, ethyl acetate fraction, compound 2 and glyasperin H (3) against human gastric carcinoma cell line SGC-7901, human hepatoma cell line SMMC-7721 and human leukemic cell line K562. All the samples exhibited significant cytotoxicity. [GRAPHICS] .
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