期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 11, 页码 1914-1918出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1644506
关键词
Eugenia gracillima; essential oil; antioxidant activity; antiprotozoal activity
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Ciencia e Tecnologia de Pernambuco (FACEPE)
- Fundacao de Amparo a Pesquisa e Desenvolvimento Cientifico do Maranhao (FAPEMA)
- Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco
- Fundacao de Amparo a Pesquisa e ao Desenvolvimento Cientifico e Tecnologico do Maranhao
- Fundacion Moises Bertoni/Laboratorios Diaz Gill
The study evaluated the volatile composition, antioxidant, and antiprotozoal activities of the essential oil obtained from leaves of Eugenia gracillima Kiaersk in the Brazilian Northeast area. The oil showed weak to moderate antioxidant activity and high selectivity against Leishmania parasites, suggesting it as a potential source for anti-Leishmania drug development.
This work evaluated the volatile composition, antioxidant and antiprotozoal activities of the essential oil obtained from leaves of Eugenia gracillima Kiaersk. (EGEO) grown in Brazilian Northeast area (Araripe, Brazil). The volatile compounds of EGEO were analyzed by GC and GC-MS and its chemical composition is mainly composed of sesquiterpene hydrocarbons (91.22%), oxygenated sesquiterpenes (7.45%) and monoterpene (1.01%). The most abundant volatile constituents of the EGEO were germacrene D (16.10%), gamma-muurolene (15.60%), bicyclogermacrene (8.53%), germacrene B (7.43%), and Delta-elemene (6.06%). The oil showed weak to moderate antioxidant activity. EGEO was highly selective to Leishmania braziliensis and Leishmania infantum promastigotes with selective indexes of 73.66 and 71.41, respectively. EGEO did not inhibit Trypanosoma cruzi. These data suggest that the E. gracillima essential oil is a relevant source of lead compounds for development of anti-Leishmania drugs.
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