期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 7, 页码 1090-1096出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1639174
关键词
Piperazic acid; JBIR-39; JBIR-40; endophyte; Streptomyces
资金
- University of Vienna
The study identified new antibacterial compounds from the culture broth of endophytic Streptomyces sp. AB100, showing its potential in drug synthesis. Only compounds with specific structures exhibited weak antibacterial activity against Gram-positive bacteria.
The culture broth of endophytic Streptomyces sp. AB100, isolated from the shoots of medicinal plant Atropa belladonna (L.) was investigated for the presence of antibacterial compounds. After initial testing followed by bioactivity-guided fractionation, six new piperazic acid (PA)-containing congeners of two known peptides, JBIR-39 and JBIR-40, were identified by HR-MS/MS and NMR analyses. Only the dehydroxylated hexapeptidic derivatives with unusual incorporation of four PA moieties exhibited weak antibacterial activity against Gram-positive test organism Bacillus subtilis. A 16S rDNA-based phylogenetic tree of known Streptomyces spp. producing PA-containing hexapeptides isolated from different habitats and endophyte Streptomyces AB100 showed considerable diversity, suggesting that these metabolites may play an important environmental role beyond their antibacterial activity. [GRAPHICS] .
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