Two new flavones glycosides with antimicrobial activities from Clerodendrum formicarum Gurke (Lamiaceae)

Clerodendrum formicarum Gurke from the Lamiaceae family is a Cameroonian medicinal plant. The crude methanol, methanol residual and ethyl acetate extracts of leaves have been phytochemically studied using chromatography column to afford four compounds; two new flavones glycoside: clerodendronone 1a (3) and clerodendronone 1b (4) along with two known compounds: 5,7-dihydroxy-4 '-methoxyflavone (1) and 5-hydroxy-7,4 '-dimethoxyflavone (2). Compound structures have been elucidated on the basis of their spectroscopy data and with literature information. The anti-microbial activities of extracts and three isolated compounds were performed. The antibacterial activity was evaluated against four gram positive, five gram negative and three fungus. Clerodendronone 1b (4) showed good antibacterial activity against bacterial gram negative Shigella flexineri NR518 (MIC = 62.5 mu g/ml) and moderate activity against Staphylococcus aureus NR46374 (MIC = 250 mu/ml). The ethyl acetate extract recorded good antibacterial activity against Staphylococcus aureus NR46003 (MIC = 125 mu g/ml) and Staphylococcus aureus NR46374 (MIC = 125 mu g/ml).

Automated summary

Clerodendrum formicarum Gurke is a Cameroonian medicinal plant from the Lamiaceae family. Phytochemical studies of its leaf extracts revealed the isolation of four compounds, with clerodendronone 1b showing good antibacterial activity against Shigella flexineri and Staphylococcus aureus. Ethyl acetate extract also exhibited good antibacterial activity against Staphylococcus aureus.