期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 10, 页码 1620-1626出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1633644
关键词
Dactylospongia elegans; meroterpenoid; cytotoxic activity
资金
- National Key Research and Development Program of China [2018YFC0310900]
- National Natural Science Foundation of China [U1605221, 41576130, 81602982, 41606173, 81703624]
- International Postdoctoral Exchange Fellowship Program [20170092]
- Shanghai Rising-Star Program [19QA1405300]
- Shanghai Municipal Health Commission Excellent Young Talent Program [2018YQ28]
Three new sesquiterpene quinones/hydroquinones and five known compounds were isolated from the marine sponge Dactylospongia elegans, with some showing activity against human cancer cell lines.
Three new sesquiterpene quinones/hydroquinones, 20-demethoxy-20-isopentylaminodactyloquinone D (1), 20-demethoxy-20-isobutylaminodactyloquinone D (2), and 19-methoxy-dictyoceratin-A (3), and five known related compounds (4-8) were isolated from the marine sponge Dactylospongia elegans. Their structures were elucidated by spectroscopic analysis, ECD calculation, single-crystal X-ray diffraction, and comparison with the literature. Compounds 3 and 5-8 exhibited activities against the human cancer cell lines DU145, SW1990, Huh7, and PANC-1 with IC50 values ranging from 2.33 to 37.85 mu M. [GRAPHICS] .
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